SH2 domain - Wikipedia
SH2 domains, and other binding domains, have been used in protein engineering to create protein assemblies. Protein assemblies are formed when several proteins bind to one another …
SH2 Domains: Folding, Binding and Therapeutical Approaches
In this review, we recapitulate the current knowledge about the structural, folding stability, and binding properties of SH2 domains and their roles in molecular pathways and pathogenesis. …
SH2 Protein Domain - Cell Signaling Technology
4 days ago · Src-homology 2 (SH2) domains are modules of approximately 100 amino acids that bind to specific phospho (pY)-containing peptide motifs. Conventional SH2 domains have a …
What Are SH2 Domains and Why Are They Important?
Jun 16, 2025 · In the immune system, SH2 domains are involved in how cells respond to cytokines, which are molecules that signal inflammation and immune activation. Proteins like …
SH2 Domains: Folding, Binding and Therapeutical Approaches
Dec 15, 2022 · In this review article, we analyze the current knowledge about the structural, folding stability, and binding properties of SH2 domains, their roles in the onset of pathological …
Introduction: History of SH2 Domains and Their Applications
Jan 15, 2017 · In this chapter, we provide a glimpse of the history of SH2 domains and describe many of the tools and techniques that have been developed along the way and discuss future …
SH2 Domain - an overview | ScienceDirect Topics
The SH2 domain is defined as a protein module that forms a pocket for binding phosphorylated tyrosine residues, facilitating interactions with specific amino acid sequences downstream, and …