RMD Open

Ultrasound-guided core needle biopsy of the parotid gland in Sjögren’s disease: a promising tool towards precision medicine

Background Disappointing outcomes in Sjögren’s disease (SjD) trials underscore the need for reliable, sensitive endpoints.
RMD Open

Unravelling IPAF, VEDOSS and connective tissue diseases classifications through the mixed connective tissue disease spectrum

Background Mixed connective tissue disease (MCTD) has long been debated as an early nonspecific phase/symptom of ...
RMD Open

Targeted proteomics identifies differentially expressed proteins in Sjögren’s disease with incident lymphoma

Objectives Patients with primary Sjögren’s disease (SjD) have an increased risk of B cell lymphoma. The aim of this study was ...
RMD Open

Impaired cardiorespiratory fitness in psoriatic arthritis: insights from cardiopulmonary exercise testing

Background Data on cardiorespiratory fitness (CRF) in psoriatic arthritis (PsA) are scarce. This study aimed to determine the ...
rmdopen.bmj

Efficacy of mycophenolate mofetil as a remission induction therapy in antineutrophil cytoplasmic antibody-associated vasculitis—a meta-analysis

Objectives A few studies on antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) treatments have shown the therapeutic efficacy of mycophenolate mofetil (MMF). However, the ...
rmdopen.bmj

Comparison between idiopathic and VEXAS-relapsing polychondritis: analysis of a French case series of 95 patients

Objective A new adult-onset autoinflammatory syndrome has been described, named VEXAS (Vacuoles, E1 Enzyme, X-linked, Autoinflammatory, Somatic). We aimed to compare the clinical characteristics, the ...
rmdopen.bmj

Cryoneurolysis versus radiofrequency ablation outcome on pain experience in chronic low back pain (COPE): a single-blinded randomised controlled trial

Objective A comparison of cryoneurolysis or radio frequency (RF) with placebo in patients with facetogenic chronic low back pain (LBP) for patient global impression of change (PGIC), pain intensity, ...
rmdopen.bmj

Patients with systemic lupus erythematosus (SLE) have an increased bisphenol A methylation score linked to SLE risk genes and selected clinical subphenotypes

Objectives Bisphenol A (BPA), a xenoestrogen that can alter DNA methylation status, has been implicated in the pathogenesis of systemic lupus erythematosus (SLE). This study aimed to investigate ...
rmdopen.bmj

Prospective study of complications and sequelae of glucocorticoid therapy in ANCA-associated vasculitis

Objective Glucocorticoids (GC) are a cornerstone in treating antineutrophil cytoplasmic antibodies-associated vasculitides (AAV), however, they add to morbidity and mortality. To date, GC toxicity in ...
rmdopen.bmj

Autoantibodies directed against the angiotensin II type 1 receptor and the endothelin-1 type A receptor in patients with systemic sclerosis

We have evaluated the clinical value of the ELISA for anti-AT 1 R AAbs and anti-ET A R AAbs in two large, clinically well-defined cohorts of SSc patients from the Netherlands. Anti-AT 1 R AAbs and ...
rmdopen.bmj

Interstitial lung disease with and without progressive fibrosing phenotype in patients with idiopathic inflammatory myopathies: data from a large multicentric cohort

Objectives Patients with connective tissue diseases can develop interstitial lung disease (ILD), leading to a progressive fibrosing ILD (PF-ILD) phenotype in some cases. We aimed to investigate the ...
rmdopen.bmj

Comparative effectiveness of biologic monotherapy versus combination therapy for patients with psoriatic arthritis: results from the Corrona registry

Objectives To characterise the comparative effectiveness of combination therapy (a tumour necrosis factor inhibitor (TNFi) and a conventional synthetic disease-modifying antirheumatic drug (csDMARD) ...