The FDA has accepted uniQure’s application for AMT-130 (now called ifezuntirgene inilparvovec), an experimental gene therapy ...

October was another busy month in Huntington’s disease (HD) research! We learned more about often-overlooked symptoms, ...

An experimental treatment for HD developed by Alnylam has shown long-lasting huntingtin lowering after just one dose, with ...

The lines between HD and catatonia may sometimes be blurred. However, recognising that occasionally there can be more than ...

Cells constantly mend tears and rips in the fabric of your DNA, like a cherished pair of jeans. Sometimes this mending can add C-A-Gs by mistake. A group of scientists examined whether other kinds of ...

HD researchers developed an AI-powered tool that analyzes a short counting task. Its speech measures reflected clinical scores and HD-related changes over time, suggesting it could be used as a remote ...

Most of us know what it’s like to have something stuck in our minds. A catchy song. A favourite YouTube video you watch again. A conversation that keeps circling in your mind. Usually, our brains move ...

August has been a packed month for Huntington’s disease (HD) research. We’ve looked at what can be learned from disappointing clinical trialclinical trial Very carefully planned experiments designed ...

A new Phase 1 study is testing SRP-1005, a huntingtin-lowering therapy given by injection under the skin. It’s early days, but this approach could add an important new arrow to the HD drug development ...

Day 3 of #HD2026 put HTT under the microscope. Researchers shared new insights into HTT1a, next-generation HTT-lowering approaches, somatic expansion, brain circuitry, and why boosting healthy HTT ...

Day 2 of #HD2026 brought us updates on the mechanics of somatic instability, new ways to track HD in people, AI tools to help drive research forward, and developments in our understanding of the HTT ...

Day 1 of HD2026 is a wrap! From what human brains can teach us about HD, to HTT1a, somatic CAG expansion and the normal biology of HTT, today’s talks spanned the spectrum from fundamental biology to ...