The Colts' 2018 campaign, which ended up being the final season of Andrew Luck's career, was a roller coaster. They started 1–5—with three losses by one possession—before going 9-1 the rest of the way to secure a wild-card playoff berth.

The Seahawks are the No. 5 seed in the NFC, holding a strength of victory tiebreaker (.478) over the Lions (.273). The Seahawks also hold the tiebreaker over the Rams for the No. 6 seed based on having a better division record than Los Angeles. Seattle is 1-1 in the NFC West while Los Angeles is 0-1.