San Francisco 49ers’ Christian McCaffrey is one of the most exciting talents in NFL. While his professional accomplishments ...

The San Francisco 49ers running back has sustained a posterior cruciate ligament (PCL) injury, head coach Kyle Shanahan ...

McCaffrey immediately checked himself out of the game and ran right into the medical tent. The 49ers star RB missed the ...

Christian McCaffrey has barely played this season ... He's one of the best players in the NFL -- when healthy. Now, he's ...

Fantasy football analyst Matt Harmon delivers his thoughts on the major happenings of Week 13's Sunday action.

San Francisco 49ers running back Christian McCaffrey suffered a knee injury and limped to the locker room in the second ...

The 49ers’ third straight defeat came in 35-10 fashion to the AFC East-clinching Buffalo Bills amid a snowstorm at Highmark ...

On a snowy night in Orchard Park, N.Y., the Buffalo Bills clinched the AFC East title with a dominant win over the San ...

The 49ers season is still trending down and now they're searching for answers on if they can get back on track.

Josh Allen and Buffalo are quickly emerging as Super Bowl favorites after delivering another stellar performance on Sunday ...

San Francisco coach Kyle Shanahan told reporters postgame that their star running back had injured the posterior cruciate ...

Josh Allen scored a receiving touchdown on a pass he threw in his latest do-everything performance, and the Buffalo Bills ...