It’s Louisville basketball vs. Creighton in March Madness to open the 2025 NCAA Tournament. Here’s what to know about the first-round game.

UofL was placed in the South Region, and their first and second round games will be played at Rupp Arena in Lexington, Ky. They're matched up against No. 1 Auburn vs. No. 16 Alabama State/St. Francis, with the top four teams in the region being Auburn, Iowa State, Michigan State and Texas A&M.

It’s Louisville Cardinals vs Creighton Bluejays to begin March Madness. Here’s our prediction for the 2025 NCAA Tournament basketball game.