Expert recap and game analysis of the San Francisco 49ers vs. Arizona Cardinals NFL game from September 21, 2025 on ESPN.

How the Cardinals find themselves at 2-5 certainly suggests they are not doing winning team things. They're on a five-game losing streak.

The 49ers (3-0) won their home opener 16-15 on Eddy Pineiro’s walk-off field goal against the Arizona Cardinals.

The NFC West didn't see their Week 7 action end until late Monday night, as the Seattle Seahawks played the final game of the week against the Houston Texans. Nothing changed in the standings, as three of the teams won their games, while the Arizona Cardinals lost their fifth consecutive game and remained in last place.

The San Francisco 49ers have not been healthy this season, and with Fred Warner and Nick Bosa out for the season, they will not be fully healthy. However, their offense has been nowhere close to the full unit all season, but there is actually some light at the end of the tunnel.

The 49ers are among six undefeated teams left after three weeks, thanks to a walk-off win over the Arizona Cardinals.

Two of the three unbeaten teams from the NFC West meet Sunday afternoon in Northern California as the Arizona Cardinals (2-0) square off against the San Francisco 49ers (2-0). This is the 49ers home opener following wins at Seattle (17-13) and at New ...

Total one-score games for NFC teams: Cardinals 7; Eagles 6; Bucs, 49ers, Seahawks 5; Cowboys, Panthers, Rams, Vikings 4; Bears, Giants, Packers, Saints 3; Commanders, Falcons 2; Lions 1.

Having the tiebreaker over Seahawks and Rams makes 49ers’ 30-19 loss to Buccaneers the least of their worries.

For the third week in a row, the Buccaneers will be locked in a battle of first-place NFC teams, this time against a visiting 49ers squad led by Christian McCaffrey on offense and Fred Warner on defen

What was the Seattle Seahawks vs Arizona Cardinals score? Look back at Thursday Night Football score updates from NFL Week 4 game on Sept. 25, 2025.