Background Arrhythmogenic cardiomyopathy (ACM) is a leading cause of sudden cardiac death in young adults and athletes. It is ...

Background Diabetes mellitus (DM) is associated with an increased risk of cardiovascular disease, but its relationship with ...

Background Up to 30% of patients with hypertrophic cardiomyopathy have the myocardial bridge (MB) mainly in the left anterior ...

Background Transcatheter aortic valve implantation (TAVI) is a well-established treatment for severe aortic stenosis but not recommended for patients with a life-expectancy below 1 year. Nevertheless, ...

Twenty years ago, writing from India, one of us described distrust as a ‘third burden’ confronting medicine. Alongside infectious and cardiovascular disease, a quieter disorder was spreading: erosion ...

Background We characterised seasonal patterns in cardiovascular (CV) mortality and hospitalisations to understand how CV health might be affected by climate change. Methods We analysed the UK Biobank ...

Background Exercise systolic blood pressure (SBP) indexed to fitness, expressed as SBP divided by peak metabolic equivalents (SBP/MET peak), is associated with cardiovascular events in patients ...

Background Discharge N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a recognised prognostic marker after transcatheter aortic valve replacement (TAVR), but its value after surgical aortic ...

Objective Gene therapies are increasingly being developed and evaluated to treat complex diseases with multiple genetic causes, including cardiovascular diseases (CVDs). However, these studies have ...

Background Hereditary transthyretin amyloidosis (ATTRv) is a rare multisystem disorder with marked phenotypic heterogeneity. Cardiac involvement, a major prognostic determinant, often develops years ...

Background Current guidelines advocate for intervention in primary mitral regurgitation (PMR) based on detection of severe MR using standardised thresholds. We sought to quantify sex-related ...