Gut

Beyond Spigelman: time-adaptive duodenal cancer risk in familial adenomatous polyposis – results from a retrospective two-centre study (DRACO)

Background Duodenal cancer is a leading cause of cancer-related mortality in familial adenomatous polyposis (FAP), yet the ...
gut.bmj

Use of genetic analysis in adult cholestatic liver disease: lessons from progressive paediatric syndromes and cohort studies

The increasing availability and decreasing costs of DNA sequencing have resulted in the re-grouping of rare, severe paediatric cases of progressive familial intrahepatic cholestasis (PFIC) with more ...
Gut

Beyond the usual suspects: haemorrhagic shock secondary to massive obscure gastrointestinal bleeding

A 49-year-old woman with alcohol-related cirrhosis (Child-Pugh B8, MELD 11) and 11 months of abstinence presented with per ...
Gut

KIF13B emerges as a key player in alcohol-associated liver steatosis

Alcohol-associated liver disease (ALD) is a major global health problem and a leading cause of liver-related morbidity and ...
Gut

From Bristol to Rome, from recurrent abdominal pain to disorders of gut-brain interaction

The first formal paediatric prevalence study of abdominal pain was conducted in 1958 in Bristol, UK. In their seminal paper Apley and Naish reported that 10–12% of their study population experienced ...
gut.bmj

Burden of liver fibrosis and steatosis coexisting with hepatitis B or C infection in China: a population-based study from the 2020 National Serological Survey

3 National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, ...
gut.bmj

Short-term risk prediction model for pancreatic cancer in type 2 diabetes: development and validation across two independent Chinese cohorts

2 Tianjin Key Laboratory of Environment, Nutrition, and Public Health, Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin, China 8 National Clinical ...
gut.bmj

GLP-1 receptor agonists versus DPP-4 inhibitors after curative resection of hepatocellular carcinoma in patients with type 2 diabetes

Liver cancer (more than 70% of cases being hepatocellular carcinoma, HCC) is the sixth most common neoplasm and the third most frequent cause of cancer death worldwide.1 In addition to well-known HCC ...
gut.bmj

Impact of non-enteric-coated pancreatic enzyme replacement therapy (NEPERT) on pain in patients with chronic pancreatitis: a double-blind, parallel-group, placebo-controlled ...

Background Pain in chronic pancreatitis (CP) is multifactorial. Efficacy of pancreatic enzyme replacement therapy (PERT) for pain remains uncertain. Objective To assess the effect of ...
gut.bmj

International expert panel review for the use of resmetirom and semaglutide in the management of MASH-related fibrosis: clinical practice update

The recent conditional US Food and Drug Administration (FDA) approval of two therapies, resmetirom (Rezdiffra) and semaglutide (Wegovy), marks the first time clinicians have pharmacological therapy ...
gut.bmj

Ferroptosis, immune activation and MASH-related HCC

Correspondence to Dr Bruno Ramos-Molina; brunoramosmolina{at}gmail.com; Dr Mohammad Shafi Kuchay; drshafikuchay{at}gmail.com Metabolic dysfunction-associated steatohepatitis (MASH) involves a complex ...
gut.bmj

Multi-kingdom signatures of the gut microbiome in Lynch syndrome: a prospective model for colorectal cancer evolution

Recent work in Gut has highlighted multi-kingdom interactions between gut bacteria and bacteriophage (‘phage’) as contributors to Crohn’s disease.1 Whether similar alterations characterise colorectal ...