The FDA has accepted uniQure’s application for AMT-130 (now called ifezuntirgene inilparvovec), an experimental gene therapy ...

HD researchers developed an AI-powered tool that analyzes a short counting task. Its speech measures reflected clinical scores and HD-related changes over time, suggesting it could be used as a remote ...

An experimental treatment for HD developed by Alnylam has shown long-lasting huntingtin lowering after just one dose, with ...

The lines between HD and catatonia may sometimes be blurred. However, recognising that occasionally there can be more than ...

For decades, Huntington’s disease (HD) research has focused on what goes wrong inside vulnerable brain cells. But neuronsneuron Brain cells that store and transmit information don’t work alone, they ...

In plain language. Written by scientists. An experimental treatment for HD developed by Alnylam has shown long-lasting huntingtin lowering after just one dose, with encouraging early safety data. A ...

Cells constantly mend tears and rips in the fabric of your DNA, like a cherished pair of jeans. Sometimes this mending can add C-A-Gs by mistake. A group of scientists examined whether other kinds of ...

Most of us know what it’s like to have something stuck in our minds. A catchy song. A favourite YouTube video you watch again. A conversation that keeps circling in your mind. Usually, our brains move ...

A change in one gene can disrupt thousands of others in HD. A study in pigs suggests an explanation: expanded huntingtin interferes with chemical marks on DNA. The same effect wasn’t seen in mice, ...

In plain language. Written by scientists. Memantine, a drug already used in Alzheimer’s disease, might help in HD, but a mouse study shows dose is everything.

In plain language. Written by scientists. Getting “stuck” on a thought, action, or conversation can be a symptom of HD—not stubbornness. New research suggests perseveration may begin earlier than ...