*RRR, NNT, and CI calculated from data in article or provided by author (Laine). †Simon = Simon LA, Weaver AS, Graham DY,et al.JAMA 1999;282:1921–8. (3 doses of celecoxib combined, 12 wk trial).
CI = confidence interval; HCC = hepatocellular carcinoma; NNS = number needed to screen; OR = odds ratio. HCC mortality 0.44% 0.54% 0.81 (0.54 to 1.22) 937/5 y HCC detected 0.92% 0.54% 1.69 (1.20 to 2 ...
Objective To determine the efficacy of ginger (either stand-alone or as an adjunct treatment) for the treatment and management of migraine headaches. Methods We searched PubMed, Embase, CINAHL, ...
Understanding the risks associated with healthcare interventions is essential for clinical decision-making and for the regulatory evaluation of new drugs. Yet, safety analyses in randomised controlled ...
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In clinical research, statistically significant effects do not necessarily indicate that an intervention provides benefits that are meaningful to patients. This is particularly important for ...
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Ethnicity data are essential in understanding how different groups are impacted by different treatments/healthcare interventions, but more work is needed in how these data should be collected, handled ...
Background Proton pump inhibitors (PPIs) have been widely used for over 35 years. However, in recent decades, numerous adverse drug reactions (ADRs) have been reported, with evidence often ...
Objectives Probability or risk outcome estimates tailored to individual patient characteristics can facilitate more personalised care, for example, regarding treatment. Yet, the uptake of prediction ...
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