San Francisco's Christian McCaffrey and George Kittle pose challenges for Houston's defense, and 49ers' pass rush will be key ...

The San Francisco 49ers enter Week 8 facing renewed questions about the health of their starting quarterback, Brock Purdy.

Kickoff from NRG Stadium is set for 1 p.m. ET, and the Texans are 1.5-point favorites, according to the latest 49ers vs.

Our expert Week 8 NFL predictions expect the 49ers to cover the spread behind All-Pro running back Christian McCaffrey!

Week 6 action kicked off bright and early in London, and there are games all throughout the day, including a trio of ...

Oct 19, 2025; Santa Clara, California, USA; San Francisco 49ers running back Christian McCaffrey (23) celebrates after a ...

NFL Week 8 odds, picks, predictions, TV channel, streaming information for the Sunday football game between San Francisco ...

The Atlanta Falcons traveled to Santa Clara, California to take on the San Francisco 49ers on "Sunday Night Football." Here's ...

The San Francisco 49ers stayed atop the NFC West with a miracle win over the Los Angeles Rams in Week 5. Here are the highlights.

My Week 7 picks went 20-10 overall and included correct upset picks of the Colts over the Chargers and the Cowboys over the ...

The San Francisco 49ers wrapped up their Week 5 game Thursday night, but they still picked up some wins Sunday.

NFL football continues with Week 7. Who plays NFL games today? What is the NFL TV schedule? See every NFL game's start time ...