C&EN

Engineering Tetrahydrodaidzein Reductase to Eliminate Reverse Catalysis for Efficient Biosynthesis of (S)-Equol

State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China Science Center for Future Foods, School of Biotechnology, Jiangnan University, Wuxi 214122, China State Key ...
C&EN

Dissecting the Mechanism of Biosynthesis of Sulfurated Biomolecules: The Case of tRNA Sulfuration

Sulfuration of biomolecules is a crucial biochemical process responsible for producing essential organic cofactors, coenzymes, vitamins, and other sulfurated biomolecules. In particular, thiomodified ...
Cancer Research

Gut Microbiota–Mediated Bile Acid Metabolism Regulates Colorectal Cancer Liver Metastasis by Altering Neutrophil Recruitment

1School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. 2Department of Oncology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, ...
Frontiers

Characterization of a sesquiterpene synthase and a short-chain dehydrogenase in zerumbone biosynthesis and the applications in engineered Saccharomyces cerevisiae

Introduction: Zerumbone is a pharmacologically active sesquiterpenoid with limited availability. This study aims to elucidate its biosynthetic pathway in Curcuma wenyujin by identifying and ...