EMBO Press

No guts, no glory: IL-26 in host-microbiota interactions

While IL-26 has been associated with a range of inflammatory conditions affecting the gut, including inflammatory bowel ...
EMBO Press

Adenovirus maturation establishes the transcription competent packaging of its genome

This study identifies DNA packaging changes during adenovirus maturation. Five distinct genomic regions are particularly ...
The EMBO Journal

Lactate supports cell-autonomous ECM production to sustain metastatic behavior in prostate cancer

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Extracellular matrix (ECM) is a major ...
The EMBO Journal

Structural insights into binding-site access and ligand recognition by human ABCB1

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. ABCB1 is a broad-spectrum efflux pump central ...
The EMBO Journal

Mutational robustness and the role of buffer genes in evolvability

Organisms rely on mutations to fuel adaptive evolution. However, many mutations impose a negative effect on fitness. Cells may have therefore evolved mechanisms that affect the phenotypic effects of ...
The EMBO Journal

Human genomic DNA is widely interspersed with i-motif structures

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. DNA i-motif structures are formed in the ...
The EMBO Journal

The septin cytoskeleton is required for plasma membrane repair

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Plasma membrane repair is a fundamental ...
The EMBO Journal

ORP5/ORP8 localize to endoplasmic reticulum–mitochondria contacts and are involved in mitochondrial function

In addition to ER–PM contact sites, ORP5 and ORP8 also localize at ER–mitochondria contacts. ORP5/ORP8 interacts with the mitochondrial protein PTPIP51. ORP5/ORP8 targeting to ER–mitochondria contact ...
The EMBO Journal

Author Correction: Lactylation-driven FTO targets CDK2 to aggravate microvascular anomalies in diabetic retinopathy

The authors contacted the journal after detecting an error in their paper. The authors provided the original source data for the affected figure. Upon review of the ...
The EMBO Journal

Gene therapy targeting key beta cell regulators as a potential intervention for diabetes

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Loss of functional beta cells is the central ...
The EMBO Journal

CTCF regulates cell cycle progression of αβ T cells in the thymus

To circumvent the problem of embryonic lethality (Fedoriw et al, 2004), we generated mice with a conditional Ctcf allele (Ctcff/f). We examined the potential function of CTCF in Tcr gene rearrangement ...
The EMBO Journal

Dectin‐1 mediates macrophage recognition of Candida albicans yeast but not filaments

The ability of Candida albicans to rapidly and reversibly switch between yeast and filamentous morphologies is crucial to pathogenicity, and it is thought that the filamentous morphology provides some ...