eLife22h
Osterix Facilitates Osteocytic Communication by Targeting Connexin43
Given their non-migratory nature within the mineralized matrix, their unique dendrites are crucial for cell-to-cell communication in response to both intracellular and extracellular stimuli, such as ...
eLife22h
Primosomal protein PriC rescues replication initiation stress by bypassing the DnaA-DnaB interaction step for DnaB helicase loading at oriC
Department of Molecular Biology, Kyushu University Graduate School of Pharmaceutical Sciences, Fukuoka, Japan ...
eLife20h
Dopamine activity encodes the changing valence of the same stimulus in conditioned taste aversion paradigms
This study utilizes an elegant approach to examine valence encoding of the mesolimbic dopamine system. The findings are valuable, demonstrating differential responses of dopamine to the same taste ...
eLife22h
Adolescent alcohol exposure promotes mechanical allodynia and alters synaptic function at inputs from the basolateral amygdala to the prelimbic cortex
The prelimbic (PrL) cortex is vulnerable to insult from adolescent alcohol exposure and receives input from the basolateral amygdala (BLA) while sending projections to the ventrolateral periaqueductal ...
eLife22h
How cancer-associated fibroblasts promote T-cell exclusion in human lung tumors: a physical perspective
Tumor cells transform fibroblasts into cancer-associated fibroblasts, which have an important immunosuppressive activity on which growth, invasion, and metastasis depend. These activated fibroblasts ...
eLife20h
Hierarchical Bayesian modeling of multi-region brain cell count data
We can now collect cell-count data across whole animal brains quantifying recent neuronal activity, gene expression, or anatomical connectivity. This is a powerful approach since it is a multi-region ...
eLife22h
Navigation: Building a cognitive map through self-motion
Mice can generate a cognitive map of an environment based on self-motion signals when there is a fixed association between their starting point and the location of their goal.
eLife1d
Water and chloride as allosteric inhibitors in WNK kinase osmosensing
WNKs sense osmotic pressure by binding specific water molecules to the inactive dimeric configuration of WNK1 and WNK3, integrating signals with chloride inhibition as demonstrated by mutagenesis and ...
eLife1d
GPRC6A as a novel kokumi receptor responsible for enhanced taste preferences by ornithine
Kokumi refers to the enhanced and more delicious state of food flavor. However, the underlying neuroscientific mechanisms remain largely unexplored. Our previous research demonstrated that ornithine ...
eLife3d
Single cell transcriptomics reveals early photoreceptor states, cell-specific transcript isoforms, and cancer-predisposing features
Here, we used deep full-length single-cell RNA-sequencing to distinguish post-mitotic cone and rod developmental states and cone-specific features that contribute to retinoblastomagenesis. The ...
eLife4d
Layer 6 corticocortical cells dominate the anatomical organization of intra and interhemispheric feedback
Sainsbury Wellcome Centre for Neuronal Circuits and Behavior, University College London, London, United Kingdom ...
eLife3d
Eed controls craniofacial osteoblast differentiation and mesenchymal proliferation from the neural crest
In this valuable study, the authors used an elegant genetic approach to delete EED at the post-neural crest induction stage. The usage of the single-cell RNA-seq analysis method is extremely suitable ...