Holly has a degree in Medical Biochemistry from the University of Leicester. Her scientific interests include genomics, personalized medicine, and bioethics.View full profile Holly has a degree in ...
Resurrecting dinosaurs using DNA retrieved from a mosquito trapped in amber is a great movie plot, though it's less likely to ...
The search space for protein engineering grows exponentially with complexity. A protein of just 100 amino acids has 20 100 possible variants—more combinations than atoms in the observable universe.
A new platform combines rational protein design with continuous evolution to discover functional molecules more efficiently. In medicine and biotechnology, the ability to evolve proteins with new or ...
Identifying DNA-binding proteins and their binding residues is critical for understanding diverse biological processes, but conventional experimental approaches are slow and costly. Existing machine ...
Protein design is crucial for the treatment of human diseases, but traditional protein design methods have some limitations. Site-directed mutagenesis is highly dependent on the physiological ...
Proteins, one of the smallest building blocks of life on Earth, hold promise for answering some of biology's biggest questions. Consisting of amino acids strung together into peptide chains, these ...
Recent advances in artificial-intelligence-based protein structure modeling have yielded remarkable progress in predicting protein structures. Because structures are constrained by their biological ...
The genetic code has given rise to the enormous diversity of proteins we see in nature—and rearranging the order of codons that make up a protein’s sequence leads to an immense variety of structure ...
Schematic of the T7-ORACLE system. The genome is maintained by the non-mutagenic host replisome (gray), while an orthogonal T7 replisome (red) maintains only a dedicated plasmid (OR) at 100,000-fold ...
Life’s most indispensable molecules are not the serene, unchanging fixtures they might appear to be. Even the proteins that guard our DNA and keep cells alive are constantly tweaking their structures ...
Making high-performance proteins for medicines or consumer products can take trial after trial of tweaks, experiments and fine-tuning. A new machine learning framework squeezes all that into a single ...
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