BUFFALO, N.Y. -- The anti-microbial activity of promising peptides shown in laboratory studies to kill several medically important fungi, some of which are resistant to current drugs, can be enhanced ...

HIV-1 protease inhibitors (PIs) have long been central to antiretroviral therapy, directly targeting the enzyme responsible for processing viral polyproteins into functional units. Their efficacy, ...

NEW YORK, NY, REHOVAT, ISRAEL, SINGAPORE, Nov. 20, 2020 (GLOBE NEWSWIRE) -- via NewMediaWire -- Todos Medical (OTCQB: TOMDF), an in vitro diagnostics company focused on distributing comprehensive ...

Patients infected with HIV-1 undergoing protease inhibitor (PI) treatment have a reduced incidence or regression of Kaposi sarcoma (KS), but the molecular mechanism of this response remains unclear.

Fuzuloparib Maintenance Therapy in Patients With Platinum-Sensitive, Recurrent Ovarian Carcinoma (FZOCUS-2): A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase III Trial In this single ...

The current most potent protease inhibitor is darunavir, which reaches levels in the blood that are nearly 1000-fold higher than needed to inhibit virus in cell culture. We will examine the pathway to ...

Forbes contributors publish independent expert analyses and insights. William A. Haseltine, Ph.D., covers genomics and regenerative medicine This article is more than 4 years old. SARS Inhibited (2006 ...

The main protease of SARS-CoV-2 (M PRO) is essential to viral replication, being highly conserved from SARS-CoV-1 through to SARS-CoV-2 and its variants. It has therefore been widely explored as a ...

As efforts to find effective antivirals to combat the SARS-CoV-2-caused COVID-19 pandemic continue, a new study explores the viral enzyme PLpro, encoded in the nonstructural protein nsp3, and its ...

Sunshine Biopharma (SBFM) has developed a new series of orally active, non-covalent protease inhibitors with dose-dependent antiviral activity in ...