Nearly 100 years ago, a seemingly simple discovery revolutionized the microscope. The introduction of phase contrast, which ...

A laser (purple) is powerfully amplified by highly polished mirrors and focused on the electron beam (blue) to shift its phase and increase the cryo-EM microscope’s contrast, allowing biologists to ...

Quantitative phase microscopies (QPMs) play a pivotal role in bio-imaging, offering unique insights that complement fluorescence imaging. They provide essential data on mass distribution and transport ...

Installed in a custom Titan Krios, the laser phase plate enhances motion correction, early‑frame recovery, and 3D classification and alignment.

Fifteen years ago, physicists worked out a method to increase image contrast by hitting the electron imaging beam with an ...

In a landmark achievement in biological imaging, researchers at the University of California, Berkeley and Biohub today ...

Optical imaging techniques have been indispensable tools for investigating living systems for many centuries. The ability to image biological systems in high resolution over space and time would allow ...

Light microscopy is a key tool that scientists use to image cells, organelles, subcellular structures, and molecules such as proteins and nucleic acids. Because visible light leaves biological ...