Discovering and bringing a new drug to market typically takes 14 years and costs approximately $ 2 billion USD. Today, the competitive landscape throughout the drug development process requires ...

Pharmacokinetic drug-drug interactions (DDIs) involving opioid analgesics can be problematic. Opioids are widely used, have a narrow therapeutic index, and can be associated with severe toxicity. The ...

One of the most comprehensive ocular pharmacokinetic studies including metabolism so far provides valuable information for ocular drug development. Severe visual illnesses are increasing in our ...

This course focuses of the study of the biochemical and physiological effects of drugs and the mechanisms of their actions. The quantitative aspects of drug absorption, distribution, metabolism, and ...

A quote from Rudolph Buchheim, an experimental pharmacologist who lived from 1820 to 1879, summarizes the nature and importance of studies in drug metabolism, including the pharmacokinetics and ...

The field of pharmacokinetics attempts to describe the bodily disposition of drugs in terms of numerical parameters that are calculated from plasma concentrations obtained at time points after drug ...

Starting in 2010, Springer will publish the European Journal of Drug Metabolism and Pharmacokinetics. All aspects of drug delivery and bioavailability are covered in the journal, which was previously ...

Effect of body position on ventricular CSF methotrexate concentration following intralumbar administration. Paclitaxel pharmacokinetics were studied in 55 courses of therapy in 30 patients. Paclitaxel ...