Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 16 (April 19, 2022), pp. 1-10 (10 pages) Allosteric modulators of G-protein-coupled receptors (GPCRs) ...
Mapping how Narcan reverses opioid overdose can provide a molecular blueprint for developing more effective drugs against ...
(THE CONVERSATION) Naloxone, also known by the brand name Narcan, is one of the most important drugs in the United States’ fight against the opioid crisis. It reverses an opioid overdose nearly ...
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Cryo-EM reveals NPFFR1 activation and guides novel ligand design
This study investigates the molecular mechanisms underlying ligand recognition, subtype selectivity, and activation of ...
Drugs that target opioid receptors sometimes have severe side effects. Thousands of people around the world die every day from overdoses involving opioids such as fentanyl. Researchers have taken a ...
Synthetic opioids like fentanyl are now the main drivers of fatal overdoses in the US, yet current treatment of the addiction is haphazard and often prohibitive. But new research has uncovered a ...
July 11 (UPI) --While scientists have long noted a complex connection between a person's addiction to opiates, or "opioid use disorder," and chronic pain, the brain mechanisms linking the two have ...
Researchers used emergent MRI technology to understand the impact of prenatal opioid exposure on early brain development and the neural mechanism behind current medications. “Choose life. Choose a job ...
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