The lab of Filippo Veglia, Ph.D., at The Wistar Institute has discovered a previously unknown mechanism for how aggressive ...

Tsukuba, Japan—Blood contains two types of neutrophils, a type of white blood cell: mature neutrophils and immature neutrophils. Under normal conditions, most neutrophils are mature and play a role in ...

Emergency hemopoiesis may maintain blood counts and a proinflammatory environment in MDS, AML, and ICUS. Altered neutrophil subset distributions in MDS and AML show diagnostic sensitivity, with ...

Figure 1: Mechanisms involved in regulation of tumor progression by neutrophil PAD4. “Using several transplantable and genetically engineered mouse models, we demonstrated that tumor growth was ...

One strategy tumors use to ensure survival involves interfering with our inherent immune response. Effective anti-tumor immunity should identify and eliminate foreign, damaged, or dying cells before ...

Medical scientists have demonstrated that important pro-inflammatory mediators are released into the bloodstream through tiny pores in the cell membrane at a very early stage of the immune response.

Heart attacks trigger a cascade of reactions in the body, and certain immune cells may worsen the damage by disrupting heart ...

A team of Japanese researchers revealed the mechanism for side effects such as fever and bone pain caused by G-CSF, which is widely used for peripheral blood hematopoietic stem cell harvesting (PBSCH) ...

People with Sweet's syndrome often wake up with a fever, body aches, and blisters on their neck, limbs and face. Also known as acute febrile neutrophilic dermatosis, it is an inflammatory skin disease ...

The European Medicines Agency’s (EMA) Pharmacovigilance Risk Assessment Committee has recommended easing routine blood count monitoring for patients on clozapine, citing new data that show that the ...