While most known types of DNA damage are fixed by our cells’ in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means that ...

Everyday DNA mutations can help us understand immune function and aging—and even mitigate harm caused by some inherited ...

Despite the significance of immune checkpoint inhibitors (ICIs) in solid tumor treatment, identifying ICI-sensitive populations remains a challenge. Mutations in DNA damage response (DDR) pathway ...

In a step toward treating mitochondrial diseases, researchers in the Netherlands have successfully edited harmful mutations in mitochondrial DNA using a genetic tool known as a base editor. The ...

Learn more about a new experimental procedure that uses cancer cells’ DNA repair system against itself to make drug-resistant ...

Cancer cells survive by repairing damage to their DNA—even damage that would normally be fatal. One of their most important ...

Scientists have corrected an extremely rare and life-threatening genetic disease of the liver in mouse models and human patient cells, using the gene-editing approach that served as the basis for the ...

The gene editing treatment targets the relatively common 1717-1G>A splicing mutation, which does not respond to many current ...

QUICK FIX: From left, Frederick Alt and Guillermo Taccioli and their colleagues identified DNA-dependent kinase as a key enzyme involved in DNA repair. The way that DNA repairs itself recently has ...

A troubling new study from MIT reveals that a common environmental contaminant, NDMA—found in polluted water, certain medications, and even processed foods—may pose a far greater cancer risk to ...