A new study finds that microglia with mutant TREM2 protein reduce brain circuit connections, promote inflammation and contribute to Alzheimer's pathology in other ways. A rare but potent genetic ...

An international research team led by Professor Kiavash Movahedi from the Brussels Center for Immunology at the Vrije Universiteit Brussel has published unexpected results in the journal Immunity.

Researchers identified OLE, a molecule derived from the PM20D1 gene, that reprograms microglia into a more protective state ...

A new study, published today in Nature Communications, offers clues into how APOE isoforms differentially affect human microglia function in Alzheimer's disease. The study, led by Dr. Sarah Marzi and ...

Chronic neuroinflammation with sustained microglial activation occurs in Parkinson’s disease (PD), yet the mechanisms and exact contribution of these cells to the neurodegeneration remains poorly ...

Age-associated microglial dysfunction contributes to the accumulation of amyloid-β (Aβ) plaques in Alzheimer’s disease. Although several studies have shown age-related declines in the phagocytic ...

New study shows that microglia cells 'listen in' to neighboring neurons and change to match them. From everyday actions like walking and talking to feats of athletic or academic excellence, the brain ...

During development, there are known sex-related differences in how microglia function. But into adulthood, there was thought to be less variation in how they behave. Microglia maintain neuronal ...

Many neurodegenerative diseases, or conditions that result from the loss of function or death of brain cells, remain largely untreatable. Most available treatments target just one of the multiple ...

This work offers new clues to when exposure to TCDD is most dangerous. Past research has found that adults exposed to TCDD did not have inflammation in the brain and there was no impact on microglia ...

A collision happens. Someone is hurt, a head injury, a concussion. Just as the first responders arrive to help the person, inside the brain, another "crew" of responders is busy clearing debris and ...