Alzheimer’s disease is marked by the buildup of amyloid plaques in the brain, but most ways of studying these deposits in mouse models require sacrificing the animals. That limits researchers’ ability ...
The App SAA mouse joins a list of knock-in models that carry a humanized Aβ sequence within the murine App gene (App knock-in (humanized Aβ), APP NL-F Knock-in, APP NL-G-F Knock-in). As in the latter ...
Multimodal correlation analysis of cognitive testing with terminal PET and immunohistochemical results in PS2APP mice at study termination. Representative PET images (z score on MRI template), ...
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