Electron microscopy has become a vital tool in structural biology, enabling researchers to visualize biological macromolecules at near-atomic resolution. Recent advances have transformed it from a low ...

Endocytosis and degradation of the membrane receptors in the lysosome controls the activation of intracellular signaling pathways, but the mechanisms that control the endocytosis itself are largely ...

Mitochondria generate most of the cell’s energy. However, when they become dysfunctional, damaged, or old, mitochondria can turn into pro-death organelles, which produce reactive oxygen species that ...

The interactions within and between the organelles inside our cells could hold the key to understanding complex diseases such as cancer and neurodegeneration. Recent advances in imaging techniques are ...

The graphic shows images of a cell under mtDNA replication stress made using so-called Correlative Light and Electron Microscopy (for short: CLEM). The mitochondrial DNA (mtDNA, green) is ejected from ...

(Nanowerk Spotlight) Scientists have long sought to decode the complex communication between cellular organelles that regulates virtually all aspects of human health and disease. Mitochondria and ...

Support grids are a key part of electron microscopy measurements; the choice of the grid can directly influence the quality and accuracy of the final image. This is particularly true for transmission ...