The ability to alter proteins to refine control over binding affinity and specificity can create tailored therapeutics with reduced side effects, highly sensitive diagnostic tools, efficient ...
What we can learn from fish calcitonin and its receptor: Evolutionary insights and medical potential
In fish, multiple HBD of CTR and stable É‘-helix of calcitonin contribute to the high binding affinity and slow dissociation, thus triggering prolonged AC/cAMP signaling. In humans, RAMP dependent ...
In a recent study published in the journal Nature, researchers from the United States of America developed the synthetic intramembrane proteolysis receptor (SNIPR) architecture to activate engineered ...
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