The enzyme RNA polymerase (RNAP) carries out transcription, copying DNA into RNA. It's the first step in gene expression, and a process fundamental to all life. But the inner workings of this ...

EM, researchers showed that water mediates catalysis and important protein interactions for RNA polymerase II function in ...

Researchers have uncovered a previously hidden layer of complexity in how genes are activated, showing that water molecules ...

Gene syntax alters DNA supercoiling to amplify or suppress nearby genes. This could improve the effectiveness of gene ...

A cell protein previously believed only to provide a scaffolding for DNA has also been shown to directly influence DNA transcription into RNA – the first step of the process by which an organism's ...

It has been confirmed that water molecules play a crucial role in 'gene transcription,' an essential step for protein ...

Every living cell must interpret its genetic code - a sequence of chemical letters that governs countless cellular functions. A new study by researchers from the Center for Theoretical Biological ...

When the molecular machinery in our cells gets to work transcribing the genetic information encoded in DNA into messenger RNA (mRNA), it pauses shortly after starting. Known as promoter-proximal ...

In this valuable study, the authors develop new approaches to investigate mRNA imprinting, a phenomenon in which RNA-protein complexes form in the nucleus to influence the fate of transcripts in the ...