The scientists at deCODE Genetics, a subsidiary of Amgen, sought to deepen the understanding of cis-acting influences of sequence variants on CpG methylation. In the study, the scientists were able to ...

CpG density and epigenetic modification state modulate DNA mechanics, altering its intrinsic compatibility with nucleosome formation.

Cancer, as a disease, starts with a change in the genome that results in the downregulation of genes involved in "normal" cell behavior. This genetic change can either be induced by a change in the ...

Cetuximab Plus Chemoradiotherapy for HIV-Associated Anal Carcinoma: A Phase II AIDS Malignancy Consortium Trial In total, 576 patients with E-HCC from four independent centers were sorted by three ...

The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated. Relationships are self-held unless noted. I = Immediate Family ...

DNA methylation is a fundamental epigenetic mechanism in which a methyl group is added onto a nucleotide, commonly cytosine. DNA methylation affects many biological processes, including gene ...

The epigenetic modification, DNA methylation, is characterized by 5-methylcytosine (5-mC) and found in specific genomic locations, most notably regulatory regions such as promoters and enhancers.