Microglia, the immune cells that protect the brain, are thought to maintain a healthy brain environment by removing unwanted substances through dynamic remodeling of the actin cytoskeleton, the cell's ...

This fully updated volume explores a wide array of new and state-of-the-art tools and resources for protein function prediction. Beginning with in-depth overviews of essential underlying computational ...

All lifeforms need to continuously adapt to temperature changes to survive. Now, Weill Cornell Medicine investigators ...

In genetics, one harmful variant can be enough to cause disease—but two can make it far more severe. One notable example is KJ, an infant diagnosed with a rare urea cycle disorder with a grim ...

Proteins are essential macromolecules that play a crucial role in virtually all biological processes. They are the building blocks of life, performing a wide range of functions within organisms, from ...

A new LMU study shows how proteins function reliably even without a stable 3D structure – and the crucial importance not only of short sequence motifs, but also of the chemical characteristics. Many ...

Making high-performance proteins for medicines or consumer products can take trial after trial of tweaks, experiments and fine-tuning. A new machine learning framework squeezes all that into a single ...