Our studies suggest that a new pathway exists for generation of C5a, especially in the absence of C3, with thrombin acting as a potent C5 convertase. It seems that when the delicate balance between ...

Scientists at Heptares Therapeutics have published the first high-resolution X-ray crystal structure of the complement C5a receptor (a G protein-coupled receptor, GPCR) binding a small molecule ...

In sepsis, activation of the complement system introduces large amounts of C5a into the circulation. The excess of this peptide paralyzes neutrophils and increases susceptibility to infection. In ...

Quantitative immunohistochemical (IHC) assessment of ataxia-telangiectasia mutated (ATM) in estrogen receptor (ER) negative early breast cancer (BC). This is an ASCO Meeting Abstract from the 2012 ...

Please provide your email address to receive an email when new articles are posted on . Targeting the complement pathway using a C5a agonist may be a “game changer” in anti-neutrophil cytoplasmic ...

It is known that dendritic cells and innate lymphoid cells type 2 (ILC2) play key roles in allergen sensitization, and humoral factors such as complement C3a and complement C5a are highly involved in ...