(A) The classic bile acid synthesis pathway: cholesterol 7α-hydroxylase (CYP7A1) converts cholesterol to 7α-hydroxycholesterol (7α-HOC). The sterol 12α-hydroxylase (CYP8B1) converts the intermediate ...
Gut-derived bile acids disrupt liver metabolism through LRH-1 before visible damage, pointing to new early biomarkers for ...
Bile acids are amphipathic steroid molecules synthesised from cholesterol in the liver and secreted into the intestine where they facilitate lipid digestion and absorption. Primary bile acids are ...
Aerobic exercise and a high capacity for exercise may protect against metabolic dysfunction-associated steatotic liver disease (MASLD), also known as fatty liver disease, by increasing the conversion ...
A comprehensive multi-omics review details how microbial metabolites, barrier breakdown, and immune circuits drive chronic ...
Bacteria naturally present in the human intestine (known as the gut microbiota) can transform cholesterol-derived bile acids into powerful metabolites that strengthen anti-cancer immunity by blocking ...
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