Ribbon structure of the BRCA2 protein. Mutations in the BRCA2 gene are linked to increased risk of breast cancer. New work from UC Davis shows how individual BRCA2 proteins work to repair damaged DNA, ...
The structural integrity of DNA is continually being challenged due to the presence of physical and chemical carcinogens in our environment. In addition to DNA lesions caused by exogenous agents, DNA ...
The study showed that oxidative stress, which is considered to contribute to cancer development, actually suppressed cancer in rats with BRCA2 gene mutations. Oxidative stress is considered to ...
Researchers found that losing a second protein, FIGNL1, allows cancer cells missing BRCA2 to restore DNA repair by reloading RAD51 onto broken DNA strands. Normally, BRCA2 helps place RAD51 at DNA ...
The initials BRCA2 may be best known for a gene associated with many cases of breast cancer, and the protein encoded by the BRCA2 gene is critical to repairing breaks in DNA. The breakdown of this ...
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