Brissett passed for 320 yards against the Colts, and he may be called on to snap the Cards' four-game losing streak.

The Cardinals are planning to start Brissett against the Packers on Sunday, Ian Rapoport of NFL Network reports. The Cardinals are on a bye Week 8, and it appears they will give Kyler Murray additional time to heal from a mid-foot sprain and target a potential return for Week 9 against the Cowboys on Monday,

The Arizona Cardinals lost in Week 6, their fourth in a row, falling to the Indianapolis Colts 31-27. Jacoby Brissett got the start at quarterback for the Cardinals, as Kyler Murray was out with a mid-foot sprain. It was their best offensive performance of the year.

As Reddit user Thacornholer discovered, the Cardinals’ net 312 passing yards marked their most since a Dec. 14, 2021, loss to the Los Angeles Rams. Arizona and Murray posted 344 net passing yards that night; Murray threw for 383 yards but lost 39 yards on four sacks.

With starting QB Kyler Murray still nursing a foot injury, backup Jacoby Brissett is likely to start for the Arizona Cardinals Sunday.

Veteran backup Jacoby Brissett was the fill-in for Cardinals franchise quarterback Kyler Murray against the Indianapolis Colts after Murray’s ailing foot kept him out of action

"Anything can happen in a 1-game sample. But Jacoby Brissett started 5 games and dropped back 188 times for Patriots last season. Brissett completed just 59% of his passes, didn’t throw for more than 168 yards in a game, threw 2 TDs. Only Will Levis was worse in EPA per dropback."

The Arizona Cardinals had its most efficient offensive game of the 2025 season, scoring 27 points and having 400 total yards of scrimmage. Sunday’s offensive success was surprising because of backup quarterback Jacoby Brissett being under center leading to this type of production.