This Saturday at 7:00 PM, the Cougars will face off against the Duke Blue Devils in a highly anticipated matchup. Fans are encouraged to Wear RED loud and proud, showing their support as the Cougars aim for victory and a chance to compete for the national championship.

NCAA Tournament Final Four matchup between the Duke Blue Devils and Houston Cougars with predictions, odds, picks, spread, betting lines and more.

The pinnacle of college basketball features a historic Final Four April 5-7 in San Antonio. All four No. 1 seeds are also historic statistical leaders. The winners of Auburn vs. Florida and Houston vs.

The stage is set for the NCAA Tournament's Final Four, which will feature two great matchups: Florida versus Auburn and Houston versus Duke.

Duke University, led by projected top NBA draft pick Cooper Flagg, will play the University of Houston in the Final Four on Saturday, April 5.

Who is the favorite to win 2025 NCAA Tournament entering Final Four games? Check out national championship odds for Auburn, Florida, Houston, Duke.

Final Four picks, predictions, odds for Duke Blue Devils vs Houston Cougars NCAA Tournament March Madness game Saturday, April 5, 2025. Who wins game?

Expect a slow-paced slugfest between Duke and Houston — and a relatively comfortable Florida win over Auburn.