Two old Pac-12 rivals turned Big Ten foes face each other in Week 13's highest-profile game. The Oregon Ducks host the USC Trojans in what will serve as a College Football Playoff elimination game for both teams.

One bettor at @BetMGM in Arizona wagered $615,000 on college football futures: $300,000 on Texas to win national championship at +500 $200,000 on Penn State to win national championship at +750 $115,000 on Clemson to win national championship at 13-1 pic.twitter.com/wdQ9sERZyb

College football Week 13 odds, picks, predictions, TV channel, streaming for Missouri Tigers vs Oklahoma Sooners SEC game on Saturday, Nov. 22, 2025.

College football Week 13 odds, picks, predictions, TV channel, streaming for Syracuse Orange vs Notre Dame Fighting Irish on Saturday, Nov. 22, 2025.

ABC and ESPN have made a lot of college football fans famous over the years. From the infamous college football superfans, like Buck-I-Guy and Big Nut at Ohio State, to the co-eds like Jenn Sterger and Katherine Webb,