The Indianapolis Colts won the game over the Arizona Cardinals in Week 6, but it was far from pretty. The defense especially struggled throughout, but thankfully, they were able to make a play when they needed it most to force a turnover on downs in the red zone to ice the game.

Jonathan Taylor’s one-yard touchdown run gave Indianapolis the lead in the fourth quarter, and the Colts withstood a final drive into the red zone by the visiting Arizona Cardinals with less than a minute left to pull out a 31-27 victory on Sunday and improve to 5-1.

What channel is Arizona Cardinals vs Indianapolis Colts game on today? How to watch NFL Week 6 football game on TV, streaming Sunday, Oct. 12, 2025.

It all came to an end on the Indianapolis 9-yard line. On fourth-and-7 with under a minute remaining, Jacoby Brissett fired beyond the reach of Trey McBride, who protested for a penalty flag that never arrived. Cornerback Chris Lammons, the nearest defender, appeared to wrap both arms around McBride at the top of his route.

The Indianapolis Colts rally in the fourth quarter to defeat the Arizona Cardinals. Here are the winners and losers from the NFL Week 6 matchup.

The Indianapolis Colts just won an incredible game against the Arizona Cardinals in what was a slobber knocker! It was a very concerning game for the Colts secondary which let the Cardinals back ups move the rock up and down the field!