The highest snow accumulations are expected east of Lake Ontario, where some isolated areas could be hit by up to 60 inches of lake-effect snow by early next week.

An arctic blast of severe cold and snow is creating hazardous conditions across the Great Lakes region over the next two days, according to the US Weather Prediction Center, potentially disrupting the plans of millions traveling the roads and skies.

An Arctic blast brought snow, frost and dangerously cold winds to the northern Plains, Midwest and Great Lakes, creating difficult travel conditions on one of the busiest travel days of the year, as millions of Americans head home from their Thanksgiving destinations.

An Arctic blast of cold air is expected to hit much of the U.S. into next week, sending temperatures plummeting. More than 230 million Americans are being impacted by the “dangerously cold” weather following a snowy and rainy Thanksgiving Day, according to FOX Weather.

Don’t forget to check the local forecast before you hit the road: Snowfall could snarl post-Thanksgiving travel plans across the northern Plains and Midwest, while roughly 9 million people are under freeze warnings in the South.

An Arctic blast gripped the northern Plains, Midwest and Great Lakes Saturday morning, with millions of Americans under freeze warnings.

The first big snow of the season threatened to bury towns in New York along lakes Erie and Ontario during a hectic holiday travel and shopping weekend.

Bone-chilling Arctic air gripped much of the eastern United States on Saturday, while lake-effect snow threatened to disrupt post-holiday travel in parts of the Great Lakes region.