The 49ers are interested in trading for Bengals edge rusher Trey Hendrickson, but Cincinnati's 2025 aspirations are a huge hurdle for SF.

The San Francisco 49ers are fighting to stay relevant in a season that keeps testing their depth. Injuries have ravaged the roster, particularly on defense, where the losses of star edge rusher Nick Bosa and linebacker Fred Warner for the year have left gaping holes in what was supposed to be an elite unit.

The San Francisco 49ers could be eyeing a former top-five pick to replace injured All-Pro pass-rusher Nick Bosa.

49ers' Kyle Shanahan downplays confrontation with receiver Jauan Jennings in loss to Bucs originally appeared on The Sporting News. Add The Sporting News as a Preferred Source by clicking here.

Any hope of the 49ers trading for a pass rusher or another impactful defender should be gone after Kyle Shanahan's latest comments.

Not long after nearly losing a fumble on a sack, Mac Jones finally unravels for the 49ers, tossing a deep pick to Jamel Dean that just might seal a home victory for Tampa Bay, which is getting heroic stuff from its own gunslinger in Baker Mayfield:

Sunday Night Football heads to the West Coast in Week 7 when the Atlanta Falcons (3-2) visit the injury-riddled San Francisco 49ers (4-2). This is SNF’s first trip to Levi’s Stadium this season, which will host Super Bowl LX on NBC on February 8, 2026.

The Buffalo Bills and San Francisco 49ers have been named possible trade suitors for a Tennessee Titans linebacker who has crossed 100 tackles in a season three times.