Pensacola is a city in the Florida Panhandle in the United States. It is the county seat and only city in Escambia County. It is the principal city o…Pensacola is a city in the Florida Panhandle in the United States. It is the county seat and only city in Escambia County. It is the principal city of the Pensacola Metropolitan Statistical Area, which had 511,503 residents in 2020. Pensacola is the first settlement established by Europeans in the United States, in 1559.
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